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Updated: Mar 29, 2026

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
Published on: June 21, 2024
Recent Advances on Genetic and Physiological Bases of In Vitro Somatic Embryo Formation
Maria Maddalena Altamura1, Federica Della Rovere2, Laura Fattorini2
1Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy. mariamaddalena.altamura@uniroma1.it.
Abstract:
Somatic embryogenesis involves a broad repertoire of genes, and complex expression patterns controlled by a concerted gene regulatory network. The present work describes this regulatory network focusing on the main aspects involved, with the aim of providing a deeper insight into understanding the total reprogramming of cells into a new organism through a somatic way. To the aim, the chromatin remodeling necessary to totipotent stem cell establishment is described, as the activity of numerous transcription factors necessary to cellular totipotency reprogramming. The eliciting effects of various plant growth regulators on the induction of somatic embryogenesis is also described and put in relation with the activity of specific transcription factors. The role of programmed cell death in the process, and the related function of specific hemoglobins as anti-stress and anti-death compounds is also described. The tools for biotechnology coming from this information is highlighted in the concluding remarks.
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