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Published on: April 7, 2023
[Critically ill pediatric hemato-oncology patient: What we do is what we should do?]
Alberto García-Salido1, Montserrat Nieto-Moro1, María Isabel Iglesias-Bouzas1
1Unidad de Cuidados Intensivos Pediátricos, Hospital Infantil Universitario Niño Jesús, Madrid, España.
Insights
Management of critically ill pediatric hemato-oncology patients (CIPHO) in Spanish PICUs shows consistent monitoring and treatment choices, with non-invasive ventilation frequently used. Further studies are needed to establish optimal care standards.
Area of Science:
- Pediatric Critical Care Medicine
- Pediatric Hematology-Oncology
- Intensive Care Unit Management
Background:
- Critically ill pediatric hemato-oncology patients (CIPHO) present unique management challenges in pediatric intensive care units (PICUs).
- Standardized care protocols for CIPHO are not universally established, necessitating an understanding of current practices.
Purpose of the Study:
- To describe the current management and monitoring strategies for CIPHO in Spanish PICUs.
- To identify potential areas for improvement in CIPHO care through a literature review.
Main Methods:
- An observational, cross-sectional, descriptive study was conducted.
- An anonymous web-based survey was distributed to 324 Spanish pediatric intensivists.
- Data were collected from 105 responding intensivists regarding treatment and monitoring practices.
Main Results:
- Treatment decisions aligned with oncologists in 59% of cases.
- Non-invasive blood pressure monitoring and intra-arterial measurements were common for hemodynamic instability.
- Non-invasive positive pressure ventilation (NIPPV) was frequently used as initial respiratory support.
- Renal replacement techniques were widely employed for acute renal failure.
- Discussions regarding withdrawal of life support involved oncologists and caregivers.
Conclusions:
- Respondents demonstrated consistent therapeutic and monitoring approaches despite the absence of a defined standard-of-care.
- The use of NIPPV as a first-line respiratory intervention is prevalent.
- Further prospective, observational, and multicenter studies are recommended to establish evidence-based management guidelines for CIPHO.
Objective:
Primary objective, to describe the management and monitorization of critically ill pediatric hemato-oncology patient (CIPHO) in the Spanish pediatric intensive care units (PICU). Secondary objective, through a literature review, to identify possible areas of improvement.
Material And Methods:
Observational transversal descriptive study. An anonymous web-based survey was sent to 324 Spanish pediatric intensivists from April 2011 to May 2011. None of them were pediatric residents.
Results:
The survey was answered by 105 intensivists, 59/105 always agreed their treatment with the oncologist. In case of hemodynamic instability, non-invasive blood pressure monitoring is always done by 85/105 and almost always optimized by intra-arterial measuring (85/105) and central venous pressure (70/105). If respiratory failure the use of non-invasive ventilation (NIPPV) is always (36/105) or frequently (60/105) established prior to conventional mechanical ventilation. To replace or withdraw non-invasive ventilation only 44/96 of the respondents to this question use a clinical protocol. Before the instauration of conventional mechanical ventilation the oncological prognosis is considered by 72/105. In case of acute oliguric renal failure the renal replacement techniques are widely used (74/105). The withdrawal of sustaining life support is frequently discussed (75/103) and agreed with the oncologist (91/103) and caregivers (81/103).
Conclusions:
In our study, despite there is not a defined standard-of-care, the respondents showed similar therapeutics and monitorization choices. The use of NIPPV as first respiratory assistance is extended. Prospective, observational and multicenter studies should be developed to establish the results of this management in this population.
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