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Serum C-reactive Protein (CRP) Level in Tuberculous Patients
N Naher1, L Helaly, Z H Sarker
1Dr Nazmun Naher, Medical Officer, Institute of Public Health, Mohakhali, Dhaka, Bangladesh.
Mymensingh Medical Journal : MMJ
|December 2, 2015
Summary
C-reactive protein (CRP) is a valuable tool for diagnosing and monitoring tuberculosis in children. Elevated CRP levels in tuberculous patients normalized after four weeks of treatment, indicating its prognostic utility.
Area of Science:
- Pediatrics
- Infectious Diseases
- Biochemistry
Background:
- Tuberculosis (TB) diagnosis and prognosis in children require reliable biomarkers.
- C-reactive protein (CRP) is an acute-phase reactant with potential diagnostic and prognostic value.
Purpose of the Study:
- To evaluate the role of C-reactive protein (CRP) levels as a diagnostic and prognostic indicator in pediatric tuberculosis patients.
Main Methods:
- A prospective case-control study involving 60 children (30 with TB, 30 healthy controls).
- Serum CRP levels were measured in tuberculosis patients and compared to healthy children.
- CRP levels were monitored during a four-week treatment period.
Main Results:
- CRP was elevated (>6 mg/L) in 83.3% of pediatric tuberculosis cases.
- A significant difference (p<0.001) in serum CRP levels was observed between TB patients and healthy children.
- CRP levels normalized in patients after four weeks of anti-tuberculosis treatment.
Conclusions:
- Serum C-reactive protein (CRP) is a useful biomarker for diagnosing tuberculosis in children.
- CRP levels can serve as a prognostic indicator, reflecting treatment response in pediatric TB patients.
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