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Triamterene and the kidney.

D A Sica1, T W Gehr

  • 1Department of Medicine, Medical College of Virginia, Richmond.

Nephron
|January 1, 1989
PubMed
Summary

Triamterene (TA), a potassium-sparing diuretic, is reviewed for its effects and adverse renal events. Clinicians must be aware of potential interactions, especially with NSAIDs, which can cause acute renal failure.

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Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Therapeutics

Background:

  • Triamterene (TA) is a potassium-sparing diuretic often used for hypertension.
  • Its use is reviewed in various populations including elderly and those with renal/hepatic dysfunction.

Purpose of the Study:

  • To review the pharmacokinetics and pharmacodynamics of Triamterene.
  • To detail reported adverse renal effects associated with Triamterene.
  • To highlight the critical interaction between Triamterene and NSAIDs.

Main Methods:

  • Literature review of Triamterene's effects.
  • Analysis of adverse event reports.
  • Focus on drug interactions, particularly with NSAIDs.

Main Results:

  • Triamterene exhibits varied pharmacokinetics/dynamics across different patient groups.
  • Adverse renal effects include urinary sediment abnormalities, nephrolithiasis, interstitial nephritis, and acute renal failure.
  • A significant risk of acute renal failure exists when Triamterene is combined with NSAIDs.

Conclusions:

  • Clinicians should be aware of Triamterene's potential adverse renal effects.
  • The combination of Triamterene and NSAIDs poses a risk for acute renal failure.
  • Awareness and monitoring are crucial for safe Triamterene use.

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