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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
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Australian Rotavirus Surveillance Program annual report, 2014.
Carl D Kirkwood1, Suzie Roczo-Farkas2,
1Senior Research Fellow, Murdoch Childrens Research Institute, Parkville, Victoria.
Communicable Diseases Intelligence Quarterly Report
|December 2, 2015
Summary
Rotavirus G12P[8] was the dominant genotype in Australia in 2014, causing significant hospitalizations. Genotype distribution varied by age and rotavirus vaccine used, showing ongoing shifts in circulating strains.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Rotavirus is a leading cause of acute gastroenteritis in children globally.
- Rotavirus vaccines have been introduced in Australia, influencing circulating strains.
- Ongoing surveillance is crucial for monitoring rotavirus genotype epidemiology.
Purpose of the Study:
- To report the rotavirus genotypes responsible for hospitalizations in Australia during 2014.
- To analyze genotype distribution by age and vaccine type.
- To understand the impact of vaccination on rotavirus epidemiology.
Main Methods:
- Collection and G and P genotype analysis of 1,022 faecal samples.
- Surveillance conducted by the Australian Rotavirus Surveillance Program.
- Analysis of 733 confirmed rotavirus positive samples.
Main Results:
- G12P[8] was the dominant genotype (29.6%) nationally.
- G1P[8] (22.9%) and G3P[8] (14.9%) were the next most common.
- Genotype distribution differed in children under 5 and was associated with specific vaccine types (RotaTeq vs. Rotarix).
Conclusions:
- G12P[8] remains a significant cause of rotavirus disease in Australia.
- Rotavirus genotype distribution shows yearly fluctuations and is influenced by vaccination.
- Continued surveillance is essential to track the dynamic wild-type rotavirus population.
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