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Targeted Therapies for Advanced Oesophagogastric Cancer: Recent Progress and Future Directions

Kate Young1, Ian Chau2

  • 1Gastrointestinal Unit, Department of Medicine, Royal Marsden Hospital, Down's Road, Sutton, Surrey, SM2 5PT, UK.

Drugs
|December 2, 2015
PubMed

Insights

Oesophagogastric cancer treatment is complex. Novel targeted therapies show promise beyond chemotherapy, addressing targets like HER-2 and VEGF, with ongoing trials for advanced disease.

Area of Science:

  • Oncology
  • Genomic Medicine
  • Translational Research

Background:

  • Oesophagogastric (OG) cancer presents a complex genomic landscape with limited survival under conventional chemotherapy.
  • Urgent need for novel therapeutic strategies due to poor prognosis in advanced OG cancer.

Purpose of the Study:

  • To review current chemotherapy rationale and clinical trials of novel agents for OG cancer.
  • To discuss emerging therapeutic targets including HER-2, EGFR, VEGF, c-Met, FGFR-2, PI3K, mTOR, and IGF-1.
  • To explore future directions such as targeting DNA repair and the immune system.

Main Methods:

  • Review of existing literature on OG cancer treatment.
  • Analysis of previously conducted and ongoing clinical trials for novel agents.
  • Discussion of targeted therapies and their associated biomarkers.

Main Results:

  • Only trastuzumab and ramucirumab are currently established targeted treatments for OG cancer.
  • Difficulties in defining predictive biomarkers hinder broader adoption of targeted therapies.
  • Numerous promising drugs are in development pipelines.

Conclusions:

  • Targeted therapies offer significant potential for improving OG cancer outcomes.
  • Overcoming biomarker challenges is crucial for advancing targeted treatment in OG cancer.
  • Future research should focus on novel approaches including DNA repair and immunotherapy.

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