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Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Protein-Protein Interfaces

Protein-Protein Interfaces

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Updated: Mar 29, 2026

AirID-Based Proximity Labeling for Protein-Protein Interaction in Plants

AirID-Based Proximity Labeling for Protein-Protein Interaction in Plants

Published on: September 16, 2022

PPIM: A Protein-Protein Interaction Database for Maize.

Guanghui Zhu¹, Aibo Wu¹, Xin-Jian Xu¹

¹Department of Computer Science and Technology, Tongji University, Shanghai 201804, China (G.Z., P.-P.X., J.W., X.-M.Z.);Key Laboratory of Food Safety Research, Institute for Nutritional Sciences (A.W.), and Key Laboratory of Systems Biology (L.C.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;Department of Mathematics, Shanghai University, Shanghai 200444, China (X.-J.X.); andMonsanto Company, St. Louis, Missouri 63167 (L.L., J.L., Y.C.).

Plant Physiology

|December 2, 2015

Summary

This summary is machine-generated.

Researchers developed the Protein-Protein Interaction Database for Maize (PPIM), a comprehensive resource detailing millions of protein interactions. This database aids in understanding maize biology, including yield and stress responses.

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Area of Science:

Agricultural Science
Bioinformatics
Systems Biology

Background:

Maize (Zea mays) is a globally significant crop.
Understanding biological processes in maize, such as yield and stress response, requires detailed protein-protein interaction (PPI) data.
Existing PPI data for maize is limited.

Purpose of the Study:

To establish a comprehensive Protein-Protein Interaction Database for Maize (PPIM).
To provide a valuable resource for researchers studying maize biology.

Main Methods:

Compiled and predicted a large-scale maize PPI network.
Integrated data from existing literature and computational predictions.
Developed a user-friendly web interface for database access.

Main Results:

The PPIM database contains 2,762,560 interactions among 14,000 maize proteins.
The database includes both predicted and literature-curated PPIs.
A powerful and accessible interface is provided at http://comp-sysbio.org/ppim.

Conclusions:

The PPIM database represents a significant advancement in maize research resources.
This resource will facilitate a deeper understanding of maize crop biology.
PPIM is expected to aid investigations into traits like yield and stress resilience.