Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Xeroderma pigmentosum.

W C Lambert

    New Jersey Medicine : the Journal of the Medical Society of New Jersey
    |May 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Xeroderma pigmentosum, a rare genetic disorder, involves defective DNA repair, making it a key model for understanding how carcinogen exposure, like sun exposure, causes cancer in the general population.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Perineal cutaneous basal cell carcinomas in patients with familial seronegative coeliac disease: report of three cases.

    The British journal of dermatology·2021
    Same author

    Comparison of adult vs. paediatric inpatients with staphylococcal scalded skin syndrome: a retrospective database analysis.

    The British journal of dermatology·2020
    Same author

    Prolonged overall survival following metastasectomy in stage IV melanoma.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2019
    Same author

    Surgical management of localized melanoma: a national cancer database retrospective review.

    The British journal of dermatology·2019
    Same author

    Declining recommended surgery in primary cutaneous melanoma: an analysis of risk factors and survival.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2019
    Same author

    How sildenafil (Viagra<sup>®</sup> ) may cause melanoma: a histopathologic study providing a potential physiological/etiopathological mechanism.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2017
    Same journal

    Putting the public back in the public health.

    New Jersey medicine : the journal of the Medical Society of New Jersey·2005
    Same journal

    Computer as consultants.

    New Jersey medicine : the journal of the Medical Society of New Jersey·2005
    Same journal

    Epilepsy in pregnancy.

    New Jersey medicine : the journal of the Medical Society of New Jersey·2005
    Same journal

    New regulation for prescriptions.

    New Jersey medicine : the journal of the Medical Society of New Jersey·2005
    Same journal

    Paradise lost: the high cost of infertility.

    New Jersey medicine : the journal of the Medical Society of New Jersey·2005
    Same journal

    Julie Goldman. The New Jersey medicine interview. Interview by Bill Berlin.

    New Jersey medicine : the journal of the Medical Society of New Jersey·2005
    See all related articles

    Area of Science:

    • Genetics
    • Oncology
    • DNA Repair

    Background:

    • Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder.
    • XP is characterized by extreme sun sensitivity and a defective DNA repair mechanism.
    • XP serves as a crucial model for studying the link between carcinogen exposure and human cancer.

    Purpose of the Study:

    • To highlight the significance of Xeroderma pigmentosum as a model for cancer etiology research.
    • To emphasize the insights gained from studying XP regarding carcinogen-induced cancer.

    Main Methods:

    • Review of laboratory studies on XP.
    • Analysis of epidemiological data related to XP.
    • Correlation of XP's DNA repair defect with cancer development.

    Related Experiment Videos

    Main Results:

    • XP provides a clear link between specific carcinogen exposure and cancer development.
    • Studies on XP offer extensive insights into the causes of cancer in the general population.
    • The defective DNA repair mechanism in XP is central to its cancer predisposition.

    Conclusions:

    • Xeroderma pigmentosum is an invaluable model for understanding cancer etiology.
    • Research on XP elucidates the role of DNA repair defects and carcinogen exposure in cancer.
    • Findings from XP research have broad implications for public health and cancer prevention strategies.