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Published on: June 12, 2021
Utilisation of bivalirudin and vascular closure devices for same-day discharge after percutaneous coronary and
Radosław J Szymański1, Radosław S Kiesz, Szymon Ł Wiernek
1San Antonio Endovascular and Heart Institute, San Antonio, TX, United States 3rd Department of Interventional Cardiology and Electrophysiology, American Heart of Poland, Dabrowa Gornicza, Poland. szymrad83@gmail.com.
Insights
Same-day discharge after percutaneous coronary intervention (PCI) and percutaneous transluminal angioplasty (PTA) is safe and feasible using bivalirudin and vascular closure devices. This approach reduces hospital stay without increasing bleeding risk in selected patients.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Vascular Surgery
Background:
- Current practice often involves overnight stays for coronary and peripheral interventions, increasing costs and hospital resource strain.
- Same-day discharge protocols aim to improve efficiency and patient convenience.
- Bivalirudin and vascular closure devices offer potential for enhanced safety in same-day discharge protocols.
Purpose of the Study:
- To assess the safety and feasibility of same-day discharge following percutaneous coronary intervention (PCI) and percutaneous transluminal angioplasty (PTA).
- To evaluate the efficacy of combining bivalirudin with vascular closure devices for same-day discharge.
- To determine if same-day discharge increases the risk of bleeding or other complications.
Main Methods:
- Retrospective analysis of 833 patients undergoing percutaneous procedures from January 2007 to February 2010.
- Patients were divided into interventional (PCI/PTA) and diagnostic groups.
- Bivalirudin and vascular closure devices were used for anticoagulation and hemostasis in the interventional group; manual compression was used in the diagnostic group.
Main Results:
- No statistically significant difference in the primary endpoint of bleeding events (GUSTO criteria) between interventional (4.0%) and diagnostic (2.6%) groups (p=0.31).
- Local vascular complication rates were similar between groups (3.1% vs. 2.9%; p=0.33).
- Interventional patients experienced earlier ambulation (117.5 vs. 131 min; p=0.003) and shorter discharge times (316.4 min vs. 214.2 min; p<0.001).
Conclusions:
- Same-day discharge after PCI and PTA using bivalirudin and vascular closure devices is safe for selected patients.
- This approach does not elevate the risk of post-procedural bleeding or complications compared to diagnostic procedures.
- The findings support the feasibility of same-day discharge, potentially reducing healthcare costs and improving hospital resource utilization.
Background:
Currently the majority of coronary and peripheral interventions are performed with an overnight stay. This increases the cost and does not reduce logistic constraints on hospital resources. We hypothesised that by combining bivalirudin with vascular closure devices we can safely discharge patients on the same day after percutaneous coronary intervention (PCI) and percutaneous transluminal angioplasty (PTA) without increasing their risk of bleeding.
Aim:
To evaluate the safety and the feasibility of same-day discharge after PCI and PTA using bivalirudin and vascular closure devices.
Methods:
This is a retrospective analysis of 833 consecutive patients who underwent percutaneous procedures in our centre between January 2007 and February 2010. The population was divided into interventional and diagnostic arms. All interventions were done with use of bivalirudin for anticoagulation and vascular closure devices for achieving haemostasis. Haemostasis in the diagnostic cohort was achieved with standard manual compression. The mean time of observation was 30 days. The mean age of patients was 64.3 years. The primary endpoint was any bleeding event meeting GUSTO criteria. The secondary endpoints included local vascular complications, major adverse cardiac and cerebrovascular events, time to ambulation and discharge, as well as need for overnight hospitalisation.
Results:
In 30-day observation the primary endpoint occurred in 4.0% of patients in the interventional group and in 2.6% of patients in the diagnostic group (p = 0.31). The frequency of local vascular complications was higher in the interventional group although it was not statistically significant (3.1% vs. 2.9%; p = 0.33). Patients from the interventional group were ambulated sooner compared to the diagnostic group (117.5 vs. 131 min; p = 0.003). Time to discharge was 316.4 ± 38.7 min and 214.2 ± 23.4 min for interventional and diagnostic procedures, respectively (p < 0.001).
Conclusions:
PCI and PTA in the selected group of patients, with use of bivalirudin and vascular closure devices, do not appear to have increased risk of post-procedural events when compared to diagnostic procedures, and can be done safely without the need for an overnight stay.
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