Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

Drug Dependence

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...

Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

Longitudinal Studies

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Social determinants of health and epigenetic clocks: a systematic review and meta-analysis of 140 studies.

Nature human behaviour·2026

Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026

Same author

Energy Spectrum of Ultrahigh-Energy Cosmic Rays across Declinations -90° to +44.8° as Measured at the Pierre Auger Observatory.

Physical review letters·2026

Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025

Same author

Social determinants of health and epigenetic clocks: Meta-analysis of 140 studies.

medRxiv : the preprint server for health sciences·2025

Same author

Search for the Anomalous Events Detected by ANITA Using the Pierre Auger Observatory.

Physical review letters·2025

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Which adolescents develop persistent substance dependence in adulthood? Using population-representative longitudinal

M H Meier¹, W Hall², A Caspi³

¹Department of Psychology,Arizona State University,Tempe,AZ,USA.

Psychological Medicine

|December 2, 2015

Summary

A simple risk score accurately identifies adolescents at risk for adult substance dependence. This tool uses nine childhood and adolescent factors to predict long-term risk, aiding early intervention strategies.

Keywords:

Longitudinal risk assessment substance dependence universal screen.

More Related Videos

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Administration of Δ⁹-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

Related Experiment Videos

Last Updated: Mar 29, 2026

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Administration of Δ⁹-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

Area of Science:

Addiction research
Adolescent psychology
Public health screening

Background:

No universal screening tools exist for substance dependence.
Existing tools lack population-based samples or simple risk aggregation.
Need for brief, inexpensive screening for adolescent substance dependence risk.

Purpose of the Study:

Develop a universal screening tool for persistent substance dependence in adulthood.
Identify adolescents at risk using a population-based sample.
Incorporate well-established risk factors with a simple algorithm.

Main Methods:

Prospective cohort study of 1037 individuals followed to age 38.
Assessed nine childhood/adolescent risk factors (family history, psychopathology, substance use, sex, SES).
Defined persistent substance dependence as 3+ instances by age 38.

Main Results:

A cumulative risk index (sum of nine factors) predicted adult substance dependence.
The index demonstrated considerable accuracy with an AUC of 0.80.
Identified key predictors for persistent substance dependence.

Conclusions:

A cumulative risk score accurately predicts adult substance dependence in the general adolescent population.
This screening approach offers a practical method for early identification.
Highlights the long-term impact of adolescent risk factors on substance dependence.