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Related Experiment Videos

Scleroderma in pregnancy.

R Maymon1, M Fejgin

  • 1Department of Obstetrics and Gynecology, A and B, Sapir Medical CenterKfar Saba, Israel.

Obstetrical & Gynecological Survey
|July 1, 1989
PubMed
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Pregnancy with scleroderma is rare and carries significant risks. This condition can lead to maternal death and fetal loss, suggesting early pregnancy termination may be advisable when complications occur.

Area of Science:

  • Rheumatology
  • Maternal-Fetal Medicine
  • Critical Care Medicine

Background:

  • Scleroderma, a rare autoimmune disease, presents unique challenges during pregnancy.
  • The interplay between scleroderma and pregnancy necessitates careful management due to potential maternal and fetal complications.

Purpose of the Study:

  • To review the literature on the rare occurrence of scleroderma in pregnant patients.
  • To assess the maternal and fetal outcomes associated with pregnancy in women with scleroderma.

Main Methods:

  • A comprehensive literature search was performed to identify case reports and studies on scleroderma and pregnancy.
  • Data on maternal mortality, fetal loss, and associated complications were extracted and analyzed.

Main Results:

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  • Ninety-four cases of scleroderma in pregnancy were identified.
  • Maternal mortality occurred in 14 patients (14.9%), primarily due to renal and cardiopulmonary complications.
  • Nineteen out of 95 fetuses (20%) were lost.

Conclusions:

  • Pregnancy in patients with scleroderma is associated with substantial maternal and fetal risks.
  • Secondary renal and cardiopulmonary involvement are major contributors to maternal mortality.
  • Prompt termination of pregnancy should be considered when severe complications arise in scleroderma patients.