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Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

381
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Decrease in microvesicle-associated tissue factor activity in morbidly obese patients after bariatric surgery.

L Ay1, J Thaler2, J-M Brix1

  • 1Department of Internal Medicine I, Rudolfstiftung Hospital Vienna, Vienna, Austria.

International Journal of Obesity (2005)
|December 2, 2015
PubMed
Summary
This summary is machine-generated.

Weight loss through bariatric surgery significantly reduces tissue factor (TF) bearing microvesicles (MVs) in morbidly obese patients. This decrease in MV-TF activity may improve their prothrombotic state.

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Area of Science:

  • Biochemistry
  • Hematology
  • Obesity Research

Background:

  • Tissue factor (TF) initiates blood coagulation and is found on microvesicles (MVs).
  • Morbid obesity is associated with increased coagulation activation and elevated TF-bearing MVs.
  • These elevated MVs may contribute to a prothrombotic state in obese individuals.

Purpose of the Study:

  • To quantify microvesicle-associated tissue factor (MV-TF) activity in morbidly obese patients.
  • To assess changes in MV-TF activity before and after weight loss via bariatric surgery.
  • To correlate MV-TF levels with clinical and metabolic parameters.

Main Methods:

  • MV-TF activity was measured using a factor Xa generation assay.
  • Seventy-four morbidly obese patients were studied before and 2 years after bariatric surgery.
  • Clinical and metabolic parameters were assessed alongside MV-TF levels.

Main Results:

  • Bariatric surgery led to significant weight loss and improved metabolic parameters.
  • Preoperative MV-TF activity correlated with C-reactive protein levels.
  • Postoperative MV-TF activity significantly decreased from 0.20 pg/ml to 0.02 pg/ml (P<0.01).

Conclusions:

  • Bariatric surgery significantly reduces MV-TF activity in morbidly obese patients.
  • The observed decrease in MV-TF activity may contribute to an improved coagulation profile post-weight loss.
  • This finding suggests a potential therapeutic target for managing thrombotic risk in obesity.