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Updated: Mar 29, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility
Hongfang Lu1, Jingang Wang, Baoan Gao
1Institute of Respiratory Diseases,Three Gorges University, Yichang, China. E-mail. 296280621@qq.com.
Objectives:
To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk.
Methods:
PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated.
Results:
Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p=0.000 for mutant homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p=0.000 for GG versus CC in the Arab descent.
Conclusion:
Our findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB.
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