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Related Experiment Video

Updated: Mar 29, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

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Published on: January 12, 2022

SD-OCT findings in polypoidal choroidal vasculopathy.

V M Asensio-Sánchez¹

¹Servicio de Oftalmología, Hospital Clínico Universitario, Valladolid, España.

Archivos De La Sociedad Espanola De Oftalmologia

|December 2, 2015

Summary

Spectral-domain optical coherence tomography (SD-OCT) imaging revealed that polypoidal choroidal vasculopathy (PCV) lesions are located in the sub-retinal pigment epithelium space. These findings suggest PCV is a variant of type 1 neovascularization.

Keywords:

Bruch membrane Choroidal neovascularisation type 1 DEP Membrana de Bruch Neovascularización coroidea tipo 1 PED Polyps Pólipos SD-OCT

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Area of Science:

Ophthalmology
Retinal Diseases
Medical Imaging

Background:

Polypoidal choroidal vasculopathy (PCV) is a subtype of exudative age-related macular degeneration.
Accurate characterization and localization of PCV lesions are crucial for effective treatment.

Purpose of the Study:

To characterize and localize polypoidal choroidal vasculopathy (PCV) lesions using spectral-domain optical coherence tomography (SD-OCT).

Main Methods:

A cohort of 10 patients (15 eyes) diagnosed with PCV underwent macular SD-OCT imaging.
SD-OCT scans were analyzed to identify lesion characteristics and anatomical location.

Main Results:

SD-OCT revealed both typical and atypical pigment epithelial detachments (PEDs) in all examined eyes.
Polyps and neovascularization associated with PCV were consistently located above Bruch's membrane.
Sub-retinal fluid (SRF) was observed in 100% of eyes with PEDs.

Conclusions:

SD-OCT imaging successfully localized the vascular lesions of PCV within the sub-retinal pigment epithelium (RPE) space.
The findings strongly support the classification of PCV as a variant of type 1 neovascularization.