Using erythromycin. Some helpful observations

Erythromycin is a very safe antibiotic that is effective against a wide variety of common and uncommon bacterial infections. Several formulations are available, each with a different absorption rate and dosing profile. The most common side effect of erythromycin is gastrointestinal intolerance, which appears to be related to disruption of intestinal motility. Gastrointestinal tolerance may be improved by limiting daily doses to less than 4 g; temporarily decreasing the total daily dose; using small doses of liquid suspension every 2, 3, or 4 hours; taking the medication with milk or food; and drinking water every 15 minutes two or three times after each dose. These measures may, in turn, improve compliance and efficacy in affected patients.