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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Inflammatory Markers and Procoagulants in Chronic Renal Disease Stages 1-4

Alma Muslimovic1, Senija Rasic1, Denijal Tulumovic2

  • 1Clinic of Nephrology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.

Medical Archives (Sarajevo, Bosnia and Herzegovina)
|December 2, 2015
PubMed

Insights

Chronic kidney disease (CKD) progression is linked to increased inflammation and clotting markers. Monitoring these inflammatory and procoagulant markers may aid in predicting cardiovascular risk in CKD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Chronic kidney disease (CKD) is a progressive condition characterized by inflammation and a hypercoagulable state.
  • This inflammatory and procoagulant state contributes to the high rates of cardiovascular morbidity and mortality observed in CKD patients.

Purpose of the Study:

  • To monitor key inflammatory and procoagulant markers across various stages (1-4) of chronic kidney disease.
  • To investigate the association between CKD progression and these biochemical markers.

Main Methods:

  • Inclusion of 120 adult subjects with CKD stages 1-4 over a 24-month period.
  • Laboratory analysis included serum creatinine, albumin, C-reactive protein (CRP), leukocytes, plasma fibrinogen, D-dimer, antithrombin III, coagulation factors VII (FC VII), and coagulation factor VIII (FC VIII).

Main Results:

  • Significant increases in CRP, fibrinogen, and FC VIII were observed with CKD progression (stages 1-4).
  • Leukocyte counts increased, and antithrombin III levels decreased, though not always statistically significant.
  • No significant differences were found in D-dimer and FC VII values across CKD stages.

Conclusions:

  • CKD progression is significantly associated with heightened inflammation.
  • These inflammatory markers hold potential for prognostic and therapeutic applications in managing CKD.
  • The established link between inflammation and cardiovascular risk suggests these biomarkers could predict outcomes and benefit early diagnosis/treatment of cardiovascular disease in CKD patients.
Abstract

Keywords:
cardiovascular morbiditycystatin Cinflammatory biomarkersprocoagulants

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