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Primary hepatic sarcomatoid carcinoma: A case report
Qianying Leng1, X I Xiang2, Yuanjiao Tang2
1Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China ; Department of Ultrasound, No.4 West China Teaching Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Experimental and Therapeutic Medicine
|December 2, 2015
Summary
This case study details a rare liver cancer, sarcomatoid carcinoma (SC), in a 60-year-old woman. Diagnosis involved imaging and immunohistochemistry, confirming primary hepatic SC (PHSC) with a poor prognosis.
Area of Science:
- Hepatology
- Oncology
- Pathology
Background:
- Sarcomatoid carcinoma (SC) is a rare malignant liver tumor with an unclear origin.
- This study presents a unique case of primary hepatic SC (PHSC) in a 60-year-old female patient.
Purpose of the Study:
- To report a rare case of primary hepatic sarcomatoid carcinoma (PHSC).
- To highlight diagnostic markers and treatment implications for PHSC.
Main Methods:
- Case presentation of a 60-year-old woman with multiple liver masses.
- Diagnostic workup included enhanced magnetic resonance imaging (MRI) and immunohistochemistry (IHC).
- Surgical resection (right hepatectomy) and cholecystectomy were performed.
Main Results:
- Immunohistochemistry confirmed PHSC with positive markers: Cytokeratin 8 (CK8), CD117, pancytokeratin, and vimentin.
- Post-operative follow-up revealed characteristic imaging signs of tumor recurrence, including peripheral enhancement, central necrosis, venous invasion, and intrahepatic metastasis.
- CK8 was identified as a critical indicator for PHSC diagnosis.
Conclusions:
- Immunohistochemistry, particularly CK8, is crucial for diagnosing PHSC.
- Surgical resection is the primary treatment, but the prognosis for PHSC remains poor.
- Characteristic imaging findings aid in detecting recurrence and metastasis.
