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Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
C-X-C motif receptor 7 in gastrointestinal cancer
Hwan-Jung Yun1, Hyewon Ryu2, Yoon Seok Choi2
1Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon 301-721, Republic of Korea ; Cancer Research Institute, Chungnam National University School of Medicine, Daejeon 301-747, Republic of Korea.
Abstract:
Chemokine receptors are key mediators of normal physiology and numerous pathological conditions, including inflammation and cancer. This receptor family is an emerging target for anticancer drug development. C-X-C motif receptor 7 (CXCR7) is an atypical chemokine receptor that was first cloned from a canine cDNA library as an orphan receptor and was initially named receptor dog cDNA 1 (RDC1). Shortly after demonstrating that RDC1 binds with its ligand, stromal cell-derived factor-1α and interferon-inducible T-cell α chemoattractant, RDC1 was officially deorphanized and renamed CXCR7, as the seventh receptor in the CXC class of the chemokine receptor family. Recent accumulating evidence has demonstrated that CXCR7 expression is augmented in the majority of tumor cells compared with their normal counterparts and is involved in cell proliferation, survival, migration, invasion and angiogenesis during the initiation and progression of breast, lung and prostate cancer. In the present review, the expression and role of CXCR7, as well as its clinical relevance in cancer of the gastrointestinal system, were investigated. In addition, the potential of this chemokine receptor as a therapeutic target in the treatment of gastrointestinal cancer was discussed.
Insights
C-X-C motif receptor 7 (CXCR7) is upregulated in many cancers and drives tumor growth. Targeting CXCR7 shows promise for treating gastrointestinal cancers.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Chemokine receptors regulate physiological and pathological processes, including cancer.
- C-X-C motif receptor 7 (CXCR7), initially known as RDC1, is an atypical chemokine receptor.
- CXCR7 expression is elevated in various tumor types and influences cancer progression.
Purpose of the Study:
- To review the expression and function of CXCR7 in gastrointestinal cancers.
- To investigate the clinical relevance of CXCR7 in gastrointestinal malignancies.
- To discuss CXCR7 as a potential therapeutic target for gastrointestinal cancer.
Main Methods:
- Literature review of studies on CXCR7 expression and function in cancer.
- Analysis of clinical data related to CXCR7 in gastrointestinal cancers.
- Evaluation of CXCR7's role in cancer cell proliferation, survival, migration, invasion, and angiogenesis.
Main Results:
- CXCR7 is overexpressed in most tumor cells compared to normal tissues.
- CXCR7 contributes to key processes in cancer initiation and progression, including proliferation, survival, migration, invasion, and angiogenesis.
- Evidence suggests CXCR7's involvement in breast, lung, and prostate cancers.
Conclusions:
- CXCR7 plays a significant role in the development and progression of gastrointestinal cancers.
- The expression and function of CXCR7 in gastrointestinal cancer warrant further investigation.
- CXCR7 represents a promising therapeutic target for gastrointestinal cancer treatment.
