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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Cerebral tumefactive demyelinating lesions.

Wei Qi¹, G E Jia¹, Xinsheng Wang¹

¹Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.

Oncology Letters

|December 2, 2015

Summary

This summary is machine-generated.

Tumefactive demyelinating lesions (TDLs) are often misdiagnosed as brain tumors. Early diagnosis using clinical and radiographic features can prevent unnecessary surgery and improve patient outcomes with steroid therapy.

Keywords:

clinical features steroid therapy tumefactive demyelinating lesions

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

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Area of Science:

Neurology
Neuro-oncology
Radiology

Background:

Tumefactive demyelinating lesions (TDLs) present a diagnostic challenge in the central nervous system.
Their presentation can mimic intracranial tumors, leading to misdiagnosis and inappropriate interventions like surgery or radiation.

Purpose of the Study:

To analyze the clinical and radiographic features of cerebral TDLs.
To evaluate the effectiveness of surgical and steroid treatment for TDLs.
To improve diagnostic accuracy and patient management.

Main Methods:

Retrospective review of 14 patients with cerebral TDLs treated between 2004 and 2009.
Analysis of clinical presentations, magnetic resonance imaging (MRI) findings, surgical methods (biopsy and resection), and histopathological confirmation.
Outcome assessment using the Karnofsky performance scale (KPS) after treatment, including steroid therapy.

Main Results:

Common presentations included hemiplegia (8/14) and increased intracranial pressure (4/14).
MRI showed isolated subcortical masses in 12/14 cases, with enhancing veins in 6/14.
Post-treatment, 13/14 patients had KPS scores ≥80, indicating satisfactory prognosis, though 2 cases recurred as multiple sclerosis.

Conclusions:

Clinical and radiographic features of TDLs are crucial for accurate pre-surgical diagnosis.
Avoiding unnecessary resection and utilizing steroid therapy can lead to favorable outcomes for TDL patients.
Distinguishing TDLs from tumors is essential to prevent complications and ensure appropriate management.