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Atherosclerosis and Liver Function Tests in Coronary Angiography Patients
Y C Doganer1,2, J E Rohrer3, U Aydogan4
1Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
The West Indian Medical Journal
|December 2, 2015
Summary
Liver function tests like alanine aminotransferase and AST show limited association with coronary artery disease. However, higher albumin levels may indicate a greater atherosclerosis burden in cardiovascular risk assessment.
Area of Science:
- Cardiology
- Hepatology
- Biochemistry
Background:
- Elevated liver enzymes, even within normal ranges, are increasingly recognized as potential indicators of cardiovascular risk.
- The relationship between normal-range liver function test variations and coronary artery disease (CAD) requires further investigation.
Purpose of the Study:
- To investigate the association between normal-range variations in liver function tests (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and albumin) and the presence and severity of coronary artery disease (CAD).
Main Methods:
- Eighty-eight patients undergoing coronary angiography were categorized into normal, non-critical (<50%), and critical (≥50%) CAD groups.
- Serum concentrations of AST, ALT, and albumin were measured and analyzed in relation to CAD severity.
Main Results:
- Albumin levels were significantly higher in patients with critical CAD compared to those with no CAD (p=0.002).
- No significant association was found between non-critical CAD and liver function tests.
- Mean AST and ALT levels were higher in patients taking aspirin, but not directly correlated with CAD severity.
Conclusions:
- Alanine aminotransferase and AST may not be reliable markers for angiographically determined coronary atherosclerosis.
- Albumin may serve as a more sensitive biomarker for assessing the extent of atherosclerosis.
- The interplay between liver function and coronary atherosclerosis is complex and warrants further research.
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