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Verbal Fluencies and Fampridine Treatment in Multiple Sclerosis

Eloi Magnin1, Yoshimasa Sagawa, Ludivine Chamard

  • 1Regional Memory Centre (CMRR), Department of Neurology, University Hospital of Besanx00E7;on, Besanx00E7;on, France.

European Neurology
|December 2, 2015
PubMed
Abstract

Insights

Fampridine may enhance cognitive processing in multiple sclerosis (MS) patients, particularly improving phonological fluency. This effect appears selective and independent of motor improvements in gait.

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Pharmacology

Background:

  • Fampridine is investigated for cognitive benefits in multiple sclerosis (MS).
  • Motor improvements may confound cognitive assessments.
  • The study aims to isolate fampridine's effects on verbal fluency in MS.

Purpose of the Study:

  • To evaluate the impact of fampridine on verbal phonological and semantic fluencies in MS patients.
  • To determine if fampridine has a selective effect on cognition, independent of motor function.

Main Methods:

  • Prospective, open-label trial with 50 MS patients (EDSS 5.3 ± 1.1).
  • Verbal fluency (phonological and semantic) assessed twice before and twice after fampridine treatment.
  • Gait velocity and fatigue also measured to assess potential confounding factors.

Main Results:

  • Significant improvements in verbal fluencies observed post-fampridine treatment.
  • No correlation found between phonological and semantic fluency improvements.
  • No significant differences in verbal fluency or fatigue between gait responders and non-responders.

Conclusions:

  • Fampridine may offer a selective procognitive benefit, specifically on phonological fluency in MS.
  • This cognitive effect is apparent even in patients who do not show gait improvement.

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