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Azithromycin Inhibits Macrophage Tumor Necrosis Factor Secretion in Response to Both Azithromycin-Susceptible and
Kim Ingram1, Matthew Marker2, Elizabeth Meals2
1Children's Foundation Research Institute at Le Bonheur Children's Hospital; Divisions of Pediatric Critical Care Medicine.
Journal of the Pediatric Infectious Diseases Society
|December 2, 2015
Abstract:
We studied the effect of azithromycin (AZM) on macrophage responses to pneumococci. We found that exposure of pneumococci to AZM led to reduced tumor necrosis factor (TNF) secretion by macrophages; this effect was observed in response to both AZM-susceptible and AZM-resistant (AZM-R) pneumococci.
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