Related Experiment Video

Updated: Mar 29, 2026

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

25.8K

[Effect of Antihypertensive Drugs on Regression of Left Ventricular Hypertrophy]

N A Koziolova, I M Shatunova

    Kardiologiia
    |December 3, 2015
    PubMed

    Insights

    Combination therapy with renin-angiotensin-aldosterone system blockers and dihydropyridine calcium antagonists is key for reducing left ventricular mass. Angiotensin II receptor blockers offer a safe and effective option for managing hypertension and left ventricular hypertrophy.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Hypertension Management

    Context:

    • Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular events.
    • Arterial hypertension is a primary driver of LVH.
    • Effective management strategies for hypertension and LVH are crucial.

    Purpose:

    • To review the role of combination therapy in reducing left ventricular myocardial mass.
    • To highlight the benefits of fixed-dose drug combinations in hypertensive patients with LVH.
    • To compare the advantages of angiotensin II receptor blockers (ARBs) in this context.

    Summary:

    • Combination treatment involving renin-angiotensin-aldosterone system (RAAS) blockers and dihydropyridine calcium antagonists effectively lowers left ventricular myocardial mass.
    • Fixed drug combinations offer advantages for patient adherence and therapeutic outcomes in arterial hypertension with LVH.
    • Angiotensin II receptor blockers demonstrate a favorable safety profile and high patient compliance compared to other antihypertensive classes.

    Impact:

    • Provides evidence supporting specific combination therapies for managing LVH in hypertensive patients.
    • Emphasizes the clinical utility of ARBs due to their safety and compliance benefits.
    • Informs clinical practice guidelines for optimizing hypertension and LVH treatment strategies.

    More Related Videos

    Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

    Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

    Published on: July 14, 2021

    5.7K
    A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats07:31

    A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

    Published on: December 2, 2016

    10.8K

    Related Concept Videos

    Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

    Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

    The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
    1.4K
    Heart Failure Drugs: Diuretics01:22

    Heart Failure Drugs: Diuretics

    Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
    1.1K
    Heart Failure Drugs: β-Blockers01:22

    Heart Failure Drugs: β-Blockers

    β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
    1.1K
    Heart Failure V: Medical Management01:30

    Heart Failure V: Medical Management

    Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
    520
    Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

    Antihypertensive Drugs: Angiotensin II Receptor Blockers

    In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
    3.0K
    Antihypertensive Drugs: Action of Diuretics01:16

    Antihypertensive Drugs: Action of Diuretics

    Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
    2.8K