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Correlation between Patterns of Mdm2 SNIP 309 and Histopathological Severity of Helicobacter pylori Associated

Taweesak Tongtawee1, Chavaboon Dechsukhum, Krajang Talabnin

  • 1Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhonrachasima, Thailand

Asian Pacific Journal of Cancer Prevention : APJCP
|December 3, 2015
PubMed
Abstract

Insights

The Mdm2 SNP309 G/G genotype is rare in Thailand, correlating with severe inflammation. Common Mdm2 SNP309 T/T and G/T genotypes are linked to mild to moderate inflammation in Helicobacter pylori gastritis.

Area of Science:

  • Genetics
  • Oncology
  • Gastroenterology

Background:

  • The tumor suppressor p53 is a key regulator of cellular responses to stress.
  • Mdm2 SNP309 acts as a negative regulator of p53.
  • Helicobacter pylori infection is a significant cause of gastritis.

Purpose of the Study:

  • To investigate the association between Mdm2 SNP309 genotypes and the severity of inflammation in H. pylori-associated gastritis.
  • To analyze the prevalence of Mdm2 SNP309 patterns in a Thai population.

Main Methods:

  • A cross-sectional study involving 100 H. pylori-infected patients.
  • Real-time PCR hybridization probe method used to detect Mdm2 SNP309 patterns in gastric mucosa specimens.
  • Results were compared with the Updated Sydney classification for inflammation grading.

Main Results:

  • Mdm2 SNP309 T/T homozygous (78%) and G/T heterozygous (19%) genotypes were common.
  • Mdm2 SNP309 G/G homozygous genotype was found in only 3% of the population.
  • T/T and G/T genotypes correlated with mild to moderate inflammation (P<0.01), while G/G correlated with severe inflammation (P<0.01).

Conclusions:

  • The low frequency of the Mdm2 SNP309 G/G genotype in the Thai population may contribute to a lower incidence of severe gastritis and gastric cancer.
  • The genetic polymorphism of Mdm2 SNP309 in Thais is associated with predominantly mild to moderate inflammation in H. pylori gastritis.

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