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Updated: Mar 29, 2026

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Published on: July 8, 2015

Transformable liquid-metal nanomedicine.

Yue Lu^1,2, Quanyin Hu^1,2, Yiliang Lin³

¹Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA.

Nature Communications

|December 3, 2015

Summary

This summary is machine-generated.

A novel liquid-metal nanomedicine offers a biodegradable and low-toxicity alternative for drug delivery. This transformable nanocarrier fuses and degrades in acidic conditions, enhancing chemotherapy efficacy in tumors.

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Last Updated: Mar 29, 2026

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Inorganic nanocarriers for drug delivery systems (DDSs) face challenges with toxicity and biodegradability.
Developing safe and effective nanomedicines is crucial for clinical applications.

Purpose of the Study:

To develop a transformable liquid-metal nanomedicine with enhanced drug delivery capabilities.
To address the limitations of traditional inorganic nanocarriers.

Main Methods:

Fabrication of core-shell nanospheres using a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell via sonication.
Loading nanoparticles with doxorubicin (Dox) and functionalizing with hyaluronic acid for tumor targeting.
Evaluating nanoparticle fusion, degradation under acidic conditions, and in vivo efficacy in xenograft tumor-bearing mice.

Main Results:

The liquid-metal nanoparticles (average diameter 107 nm) demonstrated fusion and degradation in mildly acidic environments.
Doxorubicin release was facilitated in acidic endosomes post-cellular internalization.
Hyaluronic acid conjugation enhanced chemotherapeutic inhibition in tumor models.
The nanomedicine exhibited low toxicity.

Conclusions:

A novel liquid metal-based DDS was engineered with fusible and degradable properties.
This formulation presents a promising strategy for developing low-toxicity theranostic agents.
The developed nanomedicine shows potential for improved cancer chemotherapy.