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Screening cell mechanotype by parallel microfiltration.

Dongping Qi¹, Navjot Kaur Gill¹, Chintda Santiskulvong²

¹Department of Integrative Biology and Physiology, University of California, Los Angeles, USA.

Scientific Reports

|December 3, 2015

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This summary is machine-generated.

This study introduces a new microfiltration assay to measure cell mechanotype, a key biomarker for cancer. The method reveals increased cell deformability during malignant transformation and drug resistance.

Area of Science:

Biophysics
Cell Biology
Cancer Research

Background:

Cell mechanical phenotype (mechanotype) is an emerging label-free biomarker.
Altered cell viscoelasticity is associated with malignant transformation and cancer progression.

Purpose of the Study:

To present a simple, scalable parallel microfiltration assay for measuring cell mechanotype.
To validate the assay by assessing changes in cell deformability during malignant transformation and epithelial-to-mesenchymal transition (EMT).

Main Methods:

Parallel microfiltration assay to measure cell mechanotype.
Filtration of untransformed and HRas(V12)-transformed murine ovary cells.
Induction of EMT in human ovarian cancer cells via transcription factor overexpression or drug resistance acquisition.

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Main Results:

Transformed murine cells exhibited significantly increased deformability compared to untransformed cells.
EMT induction in human ovarian cancer cells led to increased deformability.
EMT-associated changes in E-Cadherin and vimentin expression correlated with altered cell mechanotype.

Conclusions:

The parallel microfiltration assay is a validated method for screening cell mechanotype.
This technique has potential for broader clinical applications in cancer diagnostics and prognostics.