Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurotransmitters01:31

Neurotransmitters

3.8K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
3.8K
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

960
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
960
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

127
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
127
General Anesthesia: Overview01:24

General Anesthesia: Overview

995
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
995
Ovarian Cycle01:27

Ovarian Cycle

5.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
5.2K
In Vitro Fertilization01:24

In Vitro Fertilization

1.3K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anesthetic challenges of the first successful living-donor uterus transplantation in Latin America: a case report.

Clinics (Sao Paulo, Brazil)·2026
Same author

Magnesium sulfate in preeclampsia: Broad indications, not only in neurological symptoms.

Pregnancy hypertension·2024
Same author

Restrictive versus Liberal Fluid Therapy for Post-Cesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial.

Clinics (Sao Paulo, Brazil)·2020
Same author

[Management of CO<sub>2</sub> absorbent while using the anesthesia machine as a mechanical ventilator on patients with COVID-19].

Brazilian journal of anesthesiology (Elsevier)·2020
Same author

Management of CO<sub>2</sub> absorbent while using the anesthesia machine as a mechanical ventilator on patients with COVID-19.

Brazilian journal of anesthesiology (Elsevier)·2020
Same author

[Lean Six Sigma and anesthesia].

Brazilian journal of anesthesiology (Elsevier)·2019

Related Experiment Video

Updated: Mar 29, 2026

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

17.5K

[Oxytocin in cesarean-sections. What's new?].

Eduardo Tsuyoshi Yamaguchi1, Mônica Maria Siaulys2, Marcelo Luis Abramides Torres3

  • 1Hospital Universitário da Universidade de São Paulo (HU-USP), São Paulo, SP, Brasil.

Revista Brasileira De Anestesiologia
|December 3, 2015
PubMed
Summary

Oxytocin is crucial for postpartum hemorrhage, but optimal dosing during cesarean sections remains unclear. High doses may cause cardiovascular issues and reduce effectiveness due to receptor desensitization.

Keywords:
Cesarean sectionCesarianaDesensitizationDessensibilizaçãoDoseOcitocinaOxytocin

More Related Videos

External Cephalic Version: Is it an Effective and Safe Procedure?
08:49

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

16.0K
Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

8.4K

Related Experiment Videos

Last Updated: Mar 29, 2026

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

17.5K
External Cephalic Version: Is it an Effective and Safe Procedure?
08:49

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

16.0K
Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

8.4K

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology

Context:

  • Oxytocin is the primary uterotonic agent for postpartum atony.
  • Optimal oxytocin dosage and administration rates for cesarean sections lack consensus.
  • High-dose oxytocin can cause adverse cardiovascular effects, particularly in compromised patients.

Purpose:

  • To review the optimal dose and rate of oxytocin administration during cesarean sections.
  • To discuss the potential adverse effects of high-dose oxytocin.
  • To explore the phenomenon of oxytocin receptor desensitization.

Summary:

  • Current guidelines lack consensus on oxytocin's optimal dose and rate for cesarean sections.
  • High bolus doses (e.g., 10 IU) may lead to adverse cardiovascular changes.
  • Prolonged high-dose oxytocin can cause myometrial receptor desensitization, reducing clinical efficacy.

Impact:

  • Highlights the need for evidence-based guidelines on oxytocin use in cesarean sections.
  • Informs clinical practice regarding safe and effective oxytocin administration.
  • Suggests potential mechanisms for oxytocin treatment failure in postpartum hemorrhage.