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Related Experiment Video

Updated: Mar 29, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Novel technologies to engineer graft for tolerance induction.

Kyle B Woodward¹, Feng Wang, Hong Zhao

¹aDepartment of Microbiology and Immunology, Institute for Cellular Therapeutics, University of Louisville, Louisville, Kentucky, USA bOrgan Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan, Guangzhou, China *Kyle B. Woodward and Feng Wang equally contributed to the writing of this article.

Current Opinion in Organ Transplantation

|December 3, 2015

Summary

Engineered allografts with immunomodulatory molecules offer a new way to achieve transplant tolerance. This approach avoids chronic immunosuppression, enhancing graft survival and patient safety.

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Area of Science:

Transplantation immunology
Biotechnology
Regenerative medicine

Background:

Allograft rejection remains a significant challenge in transplantation.
Current immunosuppressive therapies have limitations including toxicity, side effects, and hindered transplant tolerance.
Developing strategies to induce long-term graft survival without chronic immunosuppression is crucial.

Purpose of the Study:

To review novel technologies for inducing transplant tolerance.
To explore the use of engineered grafts with immunomodulatory molecules.
To discuss the potential of localized immunomodulation for achieving transplant tolerance.

Main Methods:

Engineering cells, tissues, or solid organ grafts with immunoregulatory biologics.
Modulating the graft microenvironment to favor immune tolerance.
Analyzing the ratio of T effector cells to regulatory T cells (CD4+CD25+FoxP3+).

Main Results:

Demonstrated feasibility of engineering grafts for long-term survival without chronic immunosuppression.
Engineering grafts successfully altered the T effector/regulatory T cell balance within the graft microenvironment.
Achieved localized tolerance induction and maintenance through graft modification.

Conclusions:

Biologic-engineered allografts represent a paradigm shift for achieving long-term graft survival.
Localized immunomodulation via graft engineering minimizes immunosuppression-related adverse effects.
This approach preserves immune competency for fighting infections and cancer.