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Published on: October 6, 2023
Reversible Fluoxetine-Induced Hyperthyroidism: A Case Report
Jianbo Lai1, Dongrong Xu, Bradley S Peterson
1*Department of Mental Health, The First Affiliated Hospital, Zhejiang UniversitySchool of Medicine, Hangzhou, China; †MRI Unit, Epidemiology Division, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY; ‡Institute of the Developing Mind, Children's Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA; §The Key Laboratory of Mental Disorder's Management in Zhejiang Province; and ∥Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background:
Selective serotonin reuptake inhibitors (SSRIs) are typically used as antidepressants. Clinically significant SSRI-induced thyroid dysfunction is rare.
Case:
We report a case of hyperthyroidism induced by fluoxetine in a female patient with major depressive disorder. Her thyroid profiles indicated hyperthyroidism after a 10-week treatment with fluoxetine and were restored after discontinuation of fluoxetine and administration with venlafaxine. In the first year of follow-up, her thyroid functions as well as her depressive symptoms remained perfectly normal.
Conclusions:
This case highlights the necessity of monitoring thyroid profiles during SSRI treatment.
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