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Reversible Fluoxetine-Induced Hyperthyroidism: A Case Report.

Jianbo Lai1, Dongrong Xu, Bradley S Peterson

  • 1*Department of Mental Health, The First Affiliated Hospital, Zhejiang UniversitySchool of Medicine, Hangzhou, China; †MRI Unit, Epidemiology Division, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY; ‡Institute of the Developing Mind, Children's Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA; §The Key Laboratory of Mental Disorder's Management in Zhejiang Province; and ∥Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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Selective serotonin reuptake inhibitors (SSRIs) can rarely cause thyroid dysfunction. This case shows fluoxetine-induced hyperthyroidism, emphasizing the need for thyroid monitoring during antidepressant treatment.

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Area of Science:

  • Psychiatry
  • Endocrinology
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are primary antidepressants.
  • SSRI-induced thyroid dysfunction is an uncommon clinical event.

Observation:

  • A case of hyperthyroidism developed in a female patient with major depressive disorder during fluoxetine treatment.
  • Thyroid function normalized after discontinuing fluoxetine and initiating venlafaxine.

Findings:

  • Fluoxetine therapy was associated with the onset of hyperthyroidism.
  • Discontinuation of fluoxetine and switching to venlafaxine resolved the hyperthyroid state.

Implications:

  • Monitoring thyroid function is crucial during SSRI treatment.
  • This case underscores potential drug-induced endocrine disturbances with antidepressants.