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Updated: Mar 29, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells
10:15

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

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Heterogeneity of tumor endothelial cells and drug delivery

Kyoko Hida1, Nako Maishi1, Yu Sakurai2

  • 1Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-0815, Japan.

Advanced Drug Delivery Reviews
|December 3, 2015
PubMed

Insights

Current anti-angiogenic cancer therapy faces challenges like side-effects and resistance. This review explores targeting heterogeneous tumor endothelial cells (TECs) with novel drug delivery systems for personalized medicine.

Area of Science:

  • Oncology
  • Vascular Biology
  • Drug Delivery Systems

Background:

  • Anti-angiogenic therapy is widely used in cancer treatment but faces challenges including side-effects and drug resistance.
  • Tumor endothelial cells (TECs) exhibit distinct characteristics compared to normal endothelial cells.
  • TECs display heterogeneity that correlates with tumor malignancy status.

Purpose of the Study:

  • To review the heterogeneity of TECs within tumor vasculature.
  • To discuss novel strategies for targeting these heterogeneous tumor blood vessels.
  • To offer new perspectives on drug delivery systems for personalized cancer medicine.

Main Methods:

  • Review of existing literature on anti-angiogenic therapy and tumor vasculature.
  • Analysis of studies detailing TEC heterogeneity.
  • Discussion of a newly developed active targeting system for TECs.

Main Results:

  • Tumor endothelial cells are heterogeneous, varying with tumor malignancy.
  • Current anti-angiogenic drugs have limitations, necessitating new approaches.
  • An active targeting system specifically targeting TECs has been developed.

Conclusions:

  • Addressing TEC heterogeneity is crucial for improving cancer therapy.
  • Novel drug delivery systems targeting heterogeneous tumor vasculature offer promise.
  • Personalized medicine approaches are needed to overcome current therapeutic challenges.
Keywords:
AngiogenesisAnti-angiogenic therapyDrug deliveryHeterogeneityMENDMetastasisTumorTumor endothelial cell

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