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Skin flow and swelling in post-phlebitic limbs.

G Belcaro, D Christopoulos, A N Nicolaides

    VASA. Zeitschrift Fur Gefasskrankheiten
    |January 1, 1989
    PubMed
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    Postphlebitic limbs show increased skin blood flow and reduced venoarteriolar response (VAR), correlating with ankle swelling. These measurements objectively assess microcirculatory impairment in severe venous disease.

    Area of Science:

    • Vascular Biology
    • Microcirculation Research
    • Phlebology

    Background:

    • Postphlebitic limbs exhibit altered skin blood flow dynamics.
    • Venous insufficiency leads to reduced venoarteriolar response (VAR) and capillary hypertension.
    • Objective markers are needed to evaluate microcirculatory changes in severe venous disease.

    Purpose of the Study:

    • To objectively evaluate the degree of microcirculatory impairment in postphlebitic limbs.
    • To correlate skin flow (SF) and VAR with the rate of ankle swelling (RAS).
    • To assess the utility of SF, VAR, and RAS in studying venous hypertensive microangiopathy.

    Main Methods:

    • Laser-Doppler flowmetry was used to measure supine skin resting flow (SF) and skin flow on standing (SF).
    • Strain-gauge plethysmography measured the rate of ankle swelling (RAS).

    Related Experiment Videos

  • Venoarteriolar response (VAR) was calculated as VAR = 100 * (RF-SF)/RF in 30 normal and 70 postphlebitic limbs.

    • Main Results:

    • Postphlebitic limbs demonstrated increased SF and reduced VAR compared to normal limbs.
    • The reduction in VAR and increase in SF correlated significantly with the RAS.
    • These findings highlight objective microcirculatory changes in severe venous disease.

    Conclusions:

    • Measurements of SF, VAR, and RAS provide objective assessment of microcirculatory impairment in severe venous disease.
    • These parameters can aid in understanding the natural history of venous hypertensive microangiopathy.
    • The study supports the use of these measurements for evaluating treatment effects in venous disease.