Related Experiment Video
Updated: Mar 29, 2026
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
6.4K
Cutaneous T cell Lymphoma: an Update on Pathogenesis and Systemic Therapy
Catherine G Chung1, Brian Poligone2
1Departments of Dermatology and Pathology, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA. cchung1@hmc.psu.edu.
Current Hematologic Malignancy Reports
|December 3, 2015
Summary
Mycosis fungoides and Sézary syndrome are T cell cancers. This review explores new understandings of their development and novel systemic therapies, including HDAC inhibitors and monoclonal antibodies.
Area of Science:
- Oncology
- Dermatology
- Immunology
Background:
- Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of cutaneous T cell lymphomas (CTCL).
- These are malignancies originating from skin-homing T lymphocytes.
- Current treatment options for CTCL are limited, involving skin-directed or systemic therapies.
Purpose of the Study:
- To review emerging concepts in the pathogenesis of MF and SS.
- To discuss novel and traditional systemic therapies for MF and SS.
- To highlight advancements in understanding and treating these cutaneous lymphomas.
Main Methods:
- Literature review of recent investigations into MF and SS pathogenesis.
- Analysis of emerging therapeutic targets.
- Compilation of data on novel and traditional systemic treatments.
Main Results:
- Recent research has identified new therapeutic targets for MF and SS.
- A range of systemic therapies are available, including histone deacetylase inhibitors, monoclonal antibodies, and chemotherapy agents.
- Emerging treatments offer new hope for patients with these conditions.
Conclusions:
- Understanding the pathogenesis of MF and SS is crucial for developing effective treatments.
- Novel systemic therapies, such as HDAC inhibitors and monoclonal antibodies, show promise.
- Continued research is needed to improve outcomes for patients with CTCL.
Related Concept Videos
01:27Tumor Immunotherapy
2.2K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
01:40Cell-mediated Immune Responses
86.3K
Overview
86.3K
01:27Cytotoxic T Cells-mediated Immune Response
8.2K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
8.2K
01:30Skin Cancer
6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
01:22T Cell Activation and Clonal Selection
17.3K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
17.3K
02:17The Tumor Microenvironment
8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K