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Recent Progress in Therapeutics for Inflammation-Associated Preterm Birth: A Review
Ayumi Taguchi1,2, Aki Yamashita1,2, Kei Kawana1
11 Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Reproductive Sciences (Thousand Oaks, Calif.)
|December 3, 2015
Summary
Preventing preterm birth involves targeting inflammation caused by chorioamnionitis. Naturally derived anti-inflammatory agents offer a safe approach for pregnant women and infants.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Inflammation Research
Background:
- Preterm birth complicates 5-18% of global pregnancies.
- Acute chorioamnionitis triggers inflammation, leading to uterine contractions and cervical ripening, often preceding preterm birth.
- Microbial infections and inflammation create a cycle driving preterm delivery.
Purpose of the Study:
- To review the mechanisms of perinatal inflammation from acute chorioamnionitis.
- To summarize therapeutic strategies for resolving uterine inflammation.
- To highlight safe anti-inflammatory agents for pregnant women and neonates.
Main Methods:
- Literature review focusing on perinatal inflammation and preterm birth.
- Analysis of anti-inflammatory mechanisms and therapeutic agents.
- Synthesis of data on naturally derived compounds for safety and efficacy.
Main Results:
- Acute chorioamnionitis induces inflammatory mediators, promoting preterm birth.
- Therapeutic interventions aim to disrupt the inflammation-driven cycle.
- Naturally occurring compounds like polyphenols, omega-3 metabolites, and statins show promise.
Conclusions:
- Targeting inflammation is crucial for preventing preterm birth.
- Naturally derived anti-inflammatory agents offer a potentially safe treatment option.
- Reducing in utero inflammation protects preterm infants from adverse effects.
