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Related Experiment Video

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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
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Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals.

Fan Wu1, Eran Stark2, Pei-Cheng Ku1

  • 1Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

Neuron
|December 3, 2015
PubMed
Summary
This summary is machine-generated.

We developed a scalable silicon neural probe with integrated micro-light emitting diodes (μLEDs) and recording sites for precise optogenetic control of neural circuits in freely moving animals.

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Optogenetics

Background:

  • Optogenetic tools are crucial for understanding neural circuits.
  • Current tools often lack the spatiotemporal precision for detailed circuit analysis.
  • Scalable integration of optoelectronic components onto neural probes is needed.

Purpose of the Study:

  • To develop a scalable, monolithic optogenetic tool for high-resolution neural circuit investigation.
  • To enable precise, simultaneous optical stimulation and electrophysiological recording.
  • To facilitate cellular-level circuit analysis in deep brain structures of behaving animals.

Main Methods:

  • Fabrication of silicon neural probes with monolithically integrated micro-light emitting diodes (μLEDs) and recording sites.
  • Implantation of four-shank probes (12 μLEDs, 32 recording sites per probe) into the mouse CA1 pyramidal layer.
  • Optogenetic stimulation and electrophysiological recording in anesthetized and freely moving mice.

Main Results:

  • Robust induction of neural spikes with low light power (60 nW).
  • Induction of fast population oscillations at microwatt power levels.
  • Demonstrated precise spatiotemporal control of distinct cells and neuronal compartments.

Conclusions:

  • The developed monolithic optogenetic probe offers high scalability and spatiotemporal resolution.
  • This tool enables precise cellular-level circuit analysis in deep brain structures.
  • It provides versatility for investigating neural circuits in freely moving animals.