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Updated: Mar 29, 2026

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

First-trimester screening for congenital heart disease.

James C Huhta¹

¹Department of Perinatal Cardiology, University of Florida, Gainesville, Florida, USA.

Current Opinion in Cardiology

|December 3, 2015

Summary

First-trimester fetal heart screening is now feasible for detecting congenital heart defects (CHD) early in pregnancy. This improved screening will enhance prenatal care and outcomes for affected infants before cardiac surgery.

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Last Updated: Mar 29, 2026

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

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In utero Measurement of Heart Rate in Mouse by Noninvasive M-mode Echocardiography

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A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Area of Science:

Maternal-fetal medicine
Fetal cardiology
Prenatal diagnostics

Background:

Advances in prenatal care technology and training have increased focus on congenital heart defect (CHD) detection.
Current screening methods and postnatal protocols are insufficient for early CHD detection.
First-trimester fetal evaluations are becoming more common, necessitating improved cardiac assessment methods.

Purpose of the Study:

To establish the feasibility and effectiveness of first-trimester transvaginal heart screening for CHD detection.
To improve the selection process for fetuses requiring further fetal echocardiography.
To enhance prenatal management strategies for pregnancies complicated by CHD.

Main Methods:

Utilizing advanced ultrasound equipment for visualization of the fetal circulatory system.
Implementing transvaginal screening in the first trimester (12-13 weeks of gestation).
Focusing on otherwise uncomplicated pregnancies to identify those with potential CHD.

Main Results:

Excellent visualization of the fetal circulatory system is achievable at 12-13 weeks of gestation.
First-trimester transvaginal heart screening is demonstrated to be feasible and well-tolerated.
Technological advancements facilitate early and detailed assessment of fetal cardiac structures.

Conclusions:

Improved first-trimester fetal heart screening is expected to significantly increase CHD detection rates.
Enhanced prenatal detection will lead to better management of these patients during gestation.
Early identification facilitates timely intervention and preparation for necessary cardiac surgery.