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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Updated: Mar 29, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Operations for improving left ventricular diastolic function.

Sitaram M Emani1, Gerald R Marx

  • 1aDepartment of Cardiac Surgery, Boston Children's Hospital bDepartment of Cardiology, Children's Hospital and Department of Pediatrics, Harvard School of Medicine, Boston, Massachusetts, USA.

Current Opinion in Cardiology
|December 3, 2015
PubMed
Summary
This summary is machine-generated.

Hypoplastic left heart syndrome interventions can improve cardiac output but may lead to diastolic dysfunction. Treatment strategies focus on managing this condition and understanding endocardial fibroelastosis for better outcomes.

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Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease
  • Cardiac Surgery

Background:

  • Hypoplastic left heart syndrome (HLHS) management involves fetal and postnatal interventions to enhance left ventricular (LV) size and function.
  • Despite interventions, some HLHS patients develop persistent diastolic dysfunction, characterized by elevated left atrial and pulmonary artery pressures.
  • Diastolic dysfunction in HLHS can lead to pulmonary edema and impede the goal of biventricular circulation.

Purpose of the Study:

  • To review medical and surgical strategies for diagnosing and treating diastolic dysfunction in HLHS patients.
  • To explore the relationship between endocardial fibroelastosis and diastolic dysfunction in this population.
  • To highlight ongoing research into the causes of endocardial fibroelastosis and improved treatment modalities.

Main Methods:

  • Review of current medical and surgical approaches for HLHS.
  • Analysis of diagnostic criteria for diastolic dysfunction in pediatric cardiac patients.
  • Examination of treatment outcomes for diastolic dysfunction in HLHS.

Main Results:

  • Interventions can increase LV size and remodel the heart to support cardiac output in HLHS.
  • Diastolic dysfunction remains a significant complication, causing pulmonary edema and hypertension.
  • Endocardial fibroelastosis is frequently associated with diastolic dysfunction, impairing LV filling and mitral valve function.

Conclusions:

  • Diastolic dysfunction is a critical challenge in HLHS management, impacting long-term outcomes.
  • Endocardial fibroelastosis plays a key role in the pathophysiology of diastolic dysfunction in HLHS.
  • Further research is crucial to elucidate the mechanisms of endocardial fibroelastosis and refine therapeutic strategies for diastolic dysfunction.