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Future treatments for premature ejaculation (PE) are being explored, targeting neurotransmitters and peripheral mechanisms. Novel molecules like DA-8031 and silodosin show promise for managing this common sexual dysfunction.

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Area of Science:

  • Urology
  • Sexual Medicine
  • Pharmacology

Background:

  • Premature ejaculation (PE) is the most common male sexual dysfunction, affecting approximately 23% of men.
  • PE significantly impacts quality of life and partner satisfaction, often associated with comorbidities.
  • Current treatments for PE have limitations, including effects on sexual spontaneity and cost.

Purpose of the Study:

  • To review potential therapeutic targets for premature ejaculation.
  • To identify future therapeutic molecules for the management of PE.

Main Methods:

  • A comprehensive literature review was conducted using PubMed and Scopus.
  • Articles published until May 2015 focusing on PE and its treatment were identified.

Main Results:

  • Key central targets include serotonergic, dopaminergic, and oxytocinergic neurotransmitters, and opioid receptors.
  • Mechanisms controlling the spinal ejaculatory generator (T12-L1-2) are important therapeutic targets.
  • Peripheral interventions targeting semen transport mechanisms may also delay ejaculation.

Conclusions:

  • A diverse range of future treatment options for PE is emerging.
  • Potential novel treatments include DA-8031, Promescent, silodosin, Botulinum toxin-A, and resiniferatoxin.