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A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
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On the Possibility of Electronic DNA Nanobiochips
1Institute of Mathematical Problems of Biology, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Abstract:
We have considered as a theoretical possibility for the development of a nanobiochip the operation principle of which is based on measuring conductance in single-stranded and double-stranded DNA. Calculations have demonstrated that in the majority of cases the conductance of double-stranded nucleotides considerably exceeds that of single-stranded ones. The results obtained are in agreement with recent experiments on measuring the oligonucleotide conductance. It has been shown that an electronic biochip containing 11 nucleotide pairs will recognize ≈97% sequences. It has also been demonstrated that the percentage of identifiable sequences will grow with the sequence length.
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