Aggression in fragile X syndrome.
A C Wheeler1, M Raspa1, E Bishop1
1RTI International, Research Triangle Park, NC, USA.
Journal of Intellectual Disability Research : JIDR
|December 3, 2015
Summary
Aggressive behavior is common in fragile X syndrome (FXS), affecting most males and females. Sensory issues and anxiety are key predictors, suggesting a link to escaping uncomfortable situations.
Area of Science:
- Neurodevelopmental Disorders
- Behavioral Science
- Genetics
Background:
- Fragile X syndrome (FXS) is associated with behavioral challenges, particularly in males.
- Limited research exists on the prevalence, nature, and consequences of aggression in FXS.
Purpose of the Study:
- To investigate the prevalence, frequency, severity, and predictors of aggressive behavior in individuals with FXS.
- To understand the impact of aggression and effective management strategies in FXS.
Main Methods:
- Survey methodology employed to collect caregiver reports.
- Data gathered on types, frequency, and severity of aggressive behavior in 774 individuals with FXS.
Main Results:
- Over 90% of males and females with FXS exhibited aggression in the past year.
- Moderate to severe aggression or treatment for aggression reported in a third of males and nearly 20% of females.
- Sensory issues and hyperactivity predicted aggression frequency; sensory issues and anxiety predicted severity. Aggression in males led to caregiver or peer injuries in 30% and 22% of cases, respectively.
Conclusions:
- Aggressive behaviors are a significant concern in a subset of individuals with FXS.
- Sensory concerns predict both frequency and severity, suggesting aggression may be a response to uncomfortable stimuli.
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