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Distinguishing between stochasticity and determinism: Examples from cell cycle duration variability.

Sivan Pearl Mizrahi1,2, Oded Sandler3, Laura Lande-Diner4

  • 1Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem, Israel.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|December 3, 2015
PubMed
Summary
This summary is machine-generated.

Cell cycle variability in mammals is often stochastic but can be deterministic. Lineage analysis reveals the mammalian cell cycle duration is deterministic, possibly influenced by the circadian clock.

Keywords:
cell cycledeterminisminheritancelineagesingle cellstochasticityvariability

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Area of Science:

  • Cell Biology
  • Systems Biology
  • Chronobiology

Background:

  • Cellular variability is frequently attributed to random stochastic noise.
  • Deterministic processes can also generate variability, but distinguishing them is challenging.
  • Lineage tracing offers a powerful tool to differentiate between stochastic and deterministic cellular behaviors.

Purpose of the Study:

  • To introduce a novel approach for distinguishing stochastic from deterministic sources of variability in biological systems.
  • To investigate the nature of variability in the mammalian cell cycle.
  • To explore the potential role of the circadian clock in deterministic cell cycle processes.

Main Methods:

  • Utilizing lineage information to track cell populations over time.
  • Analyzing correlations within cell lineages to assess variability.
  • Applying the "kicked cell cycle" model to interpret findings.

Main Results:

  • Analysis of mammalian cell cycle duration within lineages demonstrated its deterministic nature.
  • Evidence suggests that the circadian clock may underlie this deterministic process.
  • The study provides a framework for understanding cell cycle variability.

Conclusions:

  • Cell cycle duration in mammals exhibits deterministic characteristics, not solely stochastic noise.
  • The circadian clock is a plausible driver of deterministic cell cycle variability.
  • Understanding these mechanisms is crucial for studying cell cycle regulation in both healthy and cancerous tissues.