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Related Experiment Video

Updated: Mar 29, 2026

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification

Published on: August 17, 2015

Target Selection during Protein Quality Control.

Sichen Shao¹, Ramanujan S Hegde¹

¹Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

Trends in Biochemical Sciences

|December 3, 2015

Summary

This summary is machine-generated.

Cells use protein quality control (QC) pathways to find and remove damaged proteins, preventing disease. These pathways employ high-fidelity recognition principles to identify aberrant proteins amidst normal ones.

Keywords:

chaperone degradation protein misfolding triage ubiquitination

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Area of Science:

Molecular Biology
Cellular Biology
Biochemistry

Background:

Protein quality control (QC) pathways are essential cellular mechanisms.
These pathways survey the proteome to identify and degrade faulty proteins.
Accumulation of aberrant proteins is linked to various human diseases.

Purpose of the Study:

To discuss the principles of high-fidelity target recognition in protein QC.
To highlight the challenges cells face in distinguishing aberrant proteins.
To guide future research in protein quality control mechanisms.

Main Methods:

Review and discussion of existing literature on protein QC pathways.
Analysis of the molecular criteria and mechanisms employed by QC machinery.
Focus on the principles of high-fidelity target recognition.

Main Results:

Protein QC pathways must assay multiple molecular criteria in spatial and temporal contexts.
Despite unique mechanisms, QC pathways share general concepts for target recognition.
High-fidelity target recognition is the critical event in all protein QC pathways.

Conclusions:

Understanding shared principles of high-fidelity recognition is key to advancing protein QC research.
Effective protein QC is crucial for maintaining cellular health and preventing disease.
Future studies should focus on elucidating these fundamental recognition principles.