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Updated: Mar 29, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Diagnostic Arthrocentesis for Suspicion of Gout Is Safe and Well Tolerated
William J Taylor1, Jaap Fransen1, Nicola Dalbeth1
1From the University of Otago, Wellington; University of Auckland, Auckland; Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand; Radboud University Medical Centre, Nijmegen; Amsterdam Rheumatology Immunology Center (ARC), Department of Rheumatology, Westfries Gasthuis, Hoorn; Rijnstate Hospital, Arnhem, the Netherlands; Boston University School of Medicine, Boston, Massachusetts; University of Pennsylvania, Philadelphia, Pennsylvania, USA; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Servicio de Reumatología, Hospital General de México, México City, México; Nasonova Research Institute of Rheumatology of Russia, Moscow, Russia; School of Medicine and Medical Science, University College Dublin; Mater Misericordiae University Hospital, Dublin, Ireland; Rheumatology Division, Hospital Universitario Cruces and BioCruces Health Research Institute, Vizcaya; Department Reumatologia, Hospital General Universitario de Elda, Alicante, Spain; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine; Institut national de la santé et de la recherche médicale (INSERM), UMR 1132, Hôpital Lariboisière; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Lariboisière, Service de Rhumatologie, Centre Viggo Petersen, Pôle Appareil Locomoteur, Paris, France; Epidemiology Unit, Italian Society for Rheumatology (SIR), Milan; Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia; Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Division of Rheumatology and Immunology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; Taichung Veterans' General Hospital; School of Medicine, China Medical University; Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Division of Rheumatology, Department of In
Objective:
To determine the frequency of adverse events of diagnostic arthrocentesis in patients with possible gout.
Methods:
Consecutive patients underwent arthrocentesis and were evaluated at 6 weeks to determine adverse events. The 95% CI were obtained by bootstrapping.
Results:
Arthrocentesis was performed in 910 patients, and 887 (97.5%) were evaluated for adverse events. Any adverse event was observed in 12 participants (1.4%, 95% CI 0.6-2.1). There was 1 case (0.1%, 95% CI 0-0.34) of septic arthritis.
Conclusions:
Diagnostic arthrocentesis is associated with a low frequency of adverse events. Septic arthritis rarely occurs.
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