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Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

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Related Experiment Video

Updated: Jul 10, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

A multidisciplinary guided practical on type I diabetes engaging students in inquiry-based learning.

M Mingueneau1, A Chaix2, N Scotti3

  • 1Centre d'Immunologie de Marseille Luminy, Aix-Marseille Université-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique, Parc Scientifique en Technologique de Luminy, Marseille, France; michael_mingueneau@biogen.com.

Advances in Physiology Education
|December 3, 2015
PubMed
Summary

This workshop improved high school students' understanding of diabetes research and scientific reasoning. Students learned about glycemia regulation and therapeutic strategies through hands-on experiments.

Keywords:
blood glucose physiologydiabeteshigh school studentsinquiry-based learningundergraduate students

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Area of Science:

  • Biomedical Sciences
  • Endocrinology
  • Science Education

Background:

  • Type I diabetes management requires understanding glycemia regulation.
  • Fundamental research is crucial for developing new therapeutic strategies.
  • Engaging students in scientific inquiry enhances learning.

Purpose of the Study:

  • To describe a 3-day workshop on type I diabetes for high school students.
  • To illustrate how glycemia regulation research informs scientific knowledge and therapies.
  • To assess the workshop's impact on student understanding of the scientific process.

Main Methods:

  • Interactive workshop format with guided and open-ended investigations.
  • Small group work with doctoral and postdoctoral mentors.
  • Student-led questioning, hypothesis generation, and experimental design.
  • Pre- and post-workshop questionnaires and poster presentations for evaluation.

Main Results:

  • Students recognized the need for animal models in diabetes research.
  • Workshop successfully enhanced student awareness of scientific reasoning.
  • Improved understanding of the research process and therapeutic development.

Conclusions:

  • Hands-on educational approaches effectively improve scientific literacy.
  • Inquiry-based learning fosters critical thinking in young students.
  • Connecting fundamental research to clinical applications motivates scientific exploration.