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Updated: Mar 29, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
Forty-five years of cell-cycle genetics
Brian J Reid1, Joseph G Culotti2, Robert S Nash3
1Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109 Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195.
Abstract:
In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.
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