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Drug induced pseudoporphyria in CKD: A case report
S Quaiser1, R Khan1, A S Khan1
1Department of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Indian Journal of Nephrology
|December 3, 2015
Summary
Pseudoporphyria (PP) is a skin disorder resembling porphyria cutanea tarda (PCT) but without biochemical abnormalities. This case highlights torsemide as a potential cause of PP in a patient with chronic kidney disease (CKD).
Area of Science:
- Dermatology
- Nephrology
- Clinical Pharmacology
Background:
- Pseudoporphyria (PP) presents with photodistributed blistering, mimicking porphyria cutanea tarda (PCT) but lacking biochemical porphyrin alterations.
- Known triggers for PP include medications, excessive sun, and ultraviolet radiation exposure.
Observation:
- A 49-year-old male patient with stage 3a chronic kidney disease (CKD) developed PP.
- The patient's PP was attributed to the intake of torsemide.
Findings:
- This case represents a potential novel association between torsemide and the development of PP.
- It is possibly the first reported instance of PP induced by torsemide in a dialysis-naive CKD patient in India.
Implications:
- This finding suggests torsemide should be considered as a potential causative agent in patients with CKD presenting with PP symptoms.
- Further research is warranted to elucidate the mechanism of torsemide-induced PP and its prevalence in CKD populations.
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