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Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Updated: Mar 29, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

The miR-149 rs2292832 T/C polymorphism may decrease digestive cancer susceptibility: an updated meta-analysis.

Lin Li¹, Tao Liu², Zuo Li³

¹Department of Rehabilitation, Shengjing Hospital of China Medical University Shenyang 110022, P. R. China.

International Journal of Clinical and Experimental Medicine

|December 3, 2015

Summary

This summary is machine-generated.

The miR-149 rs2292832 T/C single nucleotide polymorphism (SNP) is not associated with overall cancer risk. However, this SNP may slightly decrease digestive cancer risk, warranting further investigation with larger studies.

Keywords:

cancer meta-analysis miR-149 polymorphism sex smoking

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Last Updated: Mar 29, 2026

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Published on: May 10, 2024

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Published on: June 21, 2018

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Area of Science:

Genetics
Oncology
Molecular Biology

Background:

MicroRNAs (miRNAs) regulate gene expression and can act as tumor suppressors or oncogenes.
Single nucleotide polymorphisms (SNPs) in miRNA genes are linked to cancer risk, prognosis, and survival.
The association between the miR-149 rs2292832 T/C SNP and cancer risk remains uncertain.

Purpose of the Study:

To conduct an updated meta-analysis to clarify the relationship between the miR-149 rs2292832 T/C SNP and cancer risk.
To evaluate the association in various subgroups, including ethnicity, sex, smoking status, cancer type, and control source.

Main Methods:

A meta-analysis was performed on 21 case-control studies (8913 cases, 9944 controls) from PubMed and WanFang databases, published up to June 1, 2015.
Odds ratios (OR) and 95% confidence intervals (CI) were used to assess association strengths.
Subgroup analyses were conducted based on ethnicity, sex, smoking status, cancer type, and control source.

Main Results:

No significant association was found between the miR-149 rs2292832 T/C SNP and overall cancer risk.
Subgroup analyses for ethnicity, sex, and smoking status also revealed no significant associations.
A borderline significant association was detected for digestive cancer (OR = 0.90, 95% CI = 0.81-1.00) and in population-based control studies (OR = 1.15, 95% CI = 1.00-1.32).

Conclusions:

The miR-149 rs2292832 T/C SNP does not appear to increase overall cancer risk.
A potential, albeit weak, protective effect against digestive cancer may exist.
Further large-scale studies incorporating gene-environment interactions are needed to elucidate the role of miR-149 polymorphisms in cancer susceptibility.