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Correlation of serum 25-hydroxyvitamin D level with vascular calcification in hemodialysis patients

Fang Wang1, Shukun Wu1, Yizhe Ruan1

  • 1Department of Urology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital Chengdu 610072, China.

International Journal of Clinical and Experimental Medicine
|December 3, 2015
PubMed

Insights

Vitamin D deficiency is common in hemodialysis patients and linked to higher vascular calcification rates. Active treatment of vitamin D deficiency is recommended for these patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Vascular calcification is a common complication in patients undergoing maintenance hemodialysis (MHD).
  • Serum 25-hydroxyvitamin D levels are often low in MHD patients, but its association with vascular calcification requires further investigation.

Purpose of the Study:

  • To investigate the correlation between serum 25-hydroxyvitamin D levels and the prevalence and severity of vascular calcification in MHD patients.

Main Methods:

  • A cross-sectional study involving 126 MHD patients.
  • Patients were categorized into 25-hydroxyvitamin D deficiency (≤30 ηg/ml) and normal (>30 ηg/ml) groups.
  • Vascular calcification was assessed using X-ray and quantified with the Kauppila score.

Main Results:

  • 110 out of 126 patients had 25-hydroxyvitamin D deficiency.
  • The incidence of vascular calcification was significantly higher in the vitamin D deficient group (P = 0.001).
  • Serum 25-hydroxyvitamin D showed a negative correlation with calcification score (r = 0.193), though logistic regression indicated it was not an independent risk factor.

Conclusions:

  • 25-hydroxyvitamin D deficiency is prevalent in MHD patients and associated with increased vascular calcification.
  • Despite not being an independent risk factor, the findings support the need for active management of vitamin D deficiency in MHD patients.
  • Early detection and treatment of vitamin D deficiency may be crucial in managing vascular calcification in this population.
Abstract

Keywords:
25-hydroxyvitamin DMaintenance hemodialysiscalcification scorevascular calcification

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