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Prognostic value of total bilirubin in patients with angina pectoris undergoing percutaneous coronary intervention

Hai-Mu Yao1, De-Liang Shen1, Xiao-Yan Zhao1

  • 1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.

International Journal of Clinical and Experimental Medicine
|December 3, 2015
PubMed

Insights

Low serum total bilirubin (STB) levels before percutaneous coronary intervention (PCI) predict worse long-term outcomes in angina patients. This finding highlights STB as a crucial prognostic marker for cardiovascular events.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Bilirubin functions as a potent antioxidant.
  • Low serum bilirubin concentration is linked to atherosclerosis.

Purpose of the Study:

  • To determine the prognostic significance of serum total bilirubin (STB) in angina patients undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • 1419 angina patients undergoing successful PCI were analyzed.
  • Patients were stratified into high STB (≥0.49 mg/dL) and low STB (<0.49 mg/dL) groups based on pre-PCI levels.
  • Outcomes were assessed over a mean follow-up of 29 months.

Main Results:

  • In-hospital mortality and myocardial infarction rates were comparable between groups.
  • The low STB group exhibited a significantly higher incidence of death, myocardial infarction, or stroke during follow-up.
  • Low STB was identified as an independent predictor of adverse clinical outcomes (HR=1.59, P=0.031).

Conclusions:

  • Pre-PCI serum total bilirubin levels are a valuable independent predictor of long-term adverse clinical outcomes in patients with angina pectoris.
Abstract

Keywords:
Bilirubinangina pectorispercutaneous coronary intervention

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