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Yersinia pseudotuberculosis and arthritis
1Department of Microbiology, John Radcliffe Hospital, Oxford.
Abstract:
In 1986 and 1987 nine patients with a raised antibody titre to Yersinia pseudotuberculosis were found. Two of these results were almost certainly due to the cross reactivity between some Y pseudotuberculosis serogroups and some salmonella serotypes. Of the other seven patients with otherwise unexplained Y pseudotuberculosis serology, three suffered from severe arthritis and two had symptoms suggestive of sacroiliitis. Our data and published reports suggest that reactive arthritis might follow both Y enterocolitica and Y pseudotuberculosis infections.
Insights
Yersinia pseudotuberculosis infections can lead to reactive arthritis, a condition causing joint inflammation. This study identified patients with Yersinia pseudotuberculosis antibodies, linking them to arthritis and sacroiliitis symptoms.
Area of Science:
- Microbiology
- Immunology
- Rheumatology
Background:
- Yersinia infections are known triggers for reactive arthritis.
- Antibody cross-reactivity can complicate serological diagnosis.
Purpose of the Study:
- To investigate the association between Yersinia pseudotuberculosis infection and reactive arthritis.
- To identify clinical manifestations in patients with Yersinia pseudotuberculosis serology.
Main Methods:
- Serological testing for Yersinia pseudotuberculosis antibodies.
- Clinical assessment of patients for arthritis and sacroiliitis.
Main Results:
- Seven patients showed unexplained Yersinia pseudotuberculosis serology.
- Three patients developed severe arthritis; two had sacroiliitis symptoms.
Conclusions:
- Yersinia pseudotuberculosis infections are a potential cause of reactive arthritis.
- Clinical presentation may include arthritis and sacroiliitis.