Related Experiment Video
Updated: Dec 27, 2025
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
3.4K
Diffuse mesangial and endocapillary cell proliferative glomerulonephritis with persistent hypocomplementemia in a
1Shandong University Jinan 250100, P. R. China ; Department of Nephrology, People's Hospital of Dong E county Liaocheng 252200, People's P. R. China.
International Journal of Clinical and Experimental Medicine
|December 3, 2015
Summary
A 15-year-old boy with glomerulonephritis achieved complete remission of proteinuria with supportive care alone. Persistent low complement levels (C3 and C4) were observed during follow-up.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- A 15-year-old male presented with anasarca, indicating significant fluid retention.
- Laboratory results showed proteinuria, hematuria, and hypocomplementemia, suggesting kidney involvement.
Observation:
- Renal biopsy revealed diffuse mesangial and endocapillary proliferative glomerulonephritis.
- Immunofluorescence demonstrated IgG, IgA, C3, C1q, and F deposition in capillary walls and subendothelial areas.
- Electron microscopy identified subendothelial electron-dense deposits and foot process effacement.
Findings:
- The patient achieved complete remission of proteinuria within one month of supportive treatment.
- Microscopic hematuria persisted throughout the 62-week follow-up period.
- Serum complement C3 and C4 levels remained persistently low, despite clinical improvement.
Implications:
- This case highlights the potential for spontaneous remission in certain forms of glomerulonephritis.
- Persistent hypocomplementemia may not always correlate with active disease or predict poor outcomes.
- Further research is needed to understand the long-term significance of persistently low complement levels in resolved glomerulonephritis.
Keywords:
Acute glomerulonephritishypocomplementemiamesangial and endocapillary proliferative glomerulonephritisMore Related Videos
06:39Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
6.0K
07:50A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
16.3K
Related Concept Videos
01:28Chronic Kidney Disease III: Interprofessional Care
276
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
276
01:24Chronic Kidney Disease II: Clinical Manifestations
480
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
480
01:29Acute Kidney Injury III: Clinical Manifestations
690
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
690
01:26Nephrotic Syndrome II : Assessment and Medical Management
152
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
152
01:24Nephrotic Syndrome I : Introduction
416
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
416
01:20Renal Corpuscle
6.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.6K